职称：教授
职务👊🏿：杏鑫院长
邮箱：lluo@fudan.edu.cn
办公地点💶：杏鑫C105室
个人简介💅🏻：
罗凌飞杏鑫平台浩清特聘教授👹🧖🏽♀️、杏鑫注册平台院长🧔🏿♀️。1999年毕业于南京大学获学士学位👞，2004年毕业于德国哥廷根大学获博士学位，2004-2006年在德国马克斯普朗克生物物理化学研究所从事博士后研究工作。中国细胞生物学学会副理事长（2019-今）👨🏿🎨，国家自然科学基金委员会生命科学部第六、七届专家咨询委员会委员（2014-2020）、第九届国家杰出青年科学基金大评委会委员（2018-2020）。国家杰出青年科学基金获得者（2009），国家级人才计划入选者（2013、2019），中国青年五四奖章获得者（2013）☑️，国务院特殊津贴获得者（2019）👨🔧。作为首席科学家或项目负责人先后主持国家“973计划”项目（2008👼🏽⏳、2014）🔱、国家自然科学基金重大项目（2021）和国家重点研发计划项目（2021）。
研究方向🏌🏿♀️：
器官再生修复及其发育生物学基础：
本课题组以斑马鱼和小鼠为主要模式动物，以脑血管和消化器官再生修复机制及其发育生物学基础和药物开发为主要研究方向。近年来取得淋巴管和巨噬细胞在脑血管再生修复中的重要功能🗡、肝脏重度损伤下由胆管细胞转分化实现再生等重要原创性科学发现。目前课题组具体研究方向包括：1）消化器官再生的细胞与分子基础及其药物开发；2）脑血管再生修复的细胞与分子基础及其药物开发；3）消化器官发育的细胞谱系及命运决定机制研究；4）器官再生能力的物种差异及其形成机制。
Introduction and Research Interests
Dr. Lingfei Luo, Fudan-Haoqing Distinguished Professor, Dean of the School of Life Sciences, Fudan University. Dr. Luo got his bachelor degree from Nanjing University in 1999, and received his Ph.D. from the University of Goettingen, Germany, in 2004. Then, he obtained his postdoctoral training at the Max-Planck-Institute for Biophysical Chemistry in 2004-2006. He is currently the Vice President of the Chinese Society for Cell Biology, and has been the winners of the National Science Fund for Distinguished Young Scholars and China Youth May Fourth Medal. He has led several national major research project including 973 Program, NSFC Major Project, and National Key R&D Program.
Dr. Luo’s lab is focusing on the regeneration of brain vasculature and digestive organs as well as its developmental basis and drug development, using zebrafish and mouse as major model systems. Recent discoveries include novel roles of lymphatics and macrophages in brain vascular repair and regeneration, and the biliary-to-hepatocyte transdifferentiation to fulfill liver regeneration after extreme liver damages. There are four major directions in the lab: 1) Mechanisms of digestive organ regeneration and drug development. 2) Mechanisms of brain vascular regeneration and drug development. 3) Cell lineage and fate determination of digestive organ development. 4) Mechanisms underlying species difference of regenerative capabilities.
招生专业：
发育生物学👨👧👧、细胞生物学、遗传学👩🏼🎓、生物化学与分子生物学🏄🏿、生理学🧚🏼♀️、生物医学
代表性论文：
1) Jianbo He#, Shuang Li#, Zhuolin Yang, Jianlong Ma, Chuanfang Qian, Zhuofu Huang, Linke Li, Yun Yang, Jingying Chen, Yunfan Sun, Tianyu Zhao, Lingfei Luo*. (2025). Gallbladder-derived retinoic acid signalling drives reconstruction of the damaged intrahepatic biliary ducts. Nature Cell Biology27(1), 39–47.
2) Jianlong Ma#, Yang Chen#, Jingmei Song, Qingfeng Ruan, Lianghui Li, Lingfei Luo*. (2025). Establishment and application of a zebrafish model of Werner syndrome identifies sapanisertib as a potential antiaging drug. PNAS122(5), e2413719122.
3) Xintao Zhang, Huijuan Liu, Pengcheng Cai, Zhuofu Huang, Jianlong Ma*, Lingfei Luo*. (2024). Mdka produced by the activated HSCs drives bipotential progenitor cell redifferentiation during zebrafish biliary-mediated liver regeneration. Hepatologydoi: 10.1097/HEP.0000000000001031. Online ahead of print.
4) Jingying Chen*, Jing Ding, Yongyu Li, Fujuan Feng, Yuhang Xu, Tao Wang, Jianbo He, Jing Cang, Lingfei Luo*. (2024). Epidermal growth factor-like domain 7 drives brain lymphatic endothelial cell development through integrin αvβ3. Nature Communications 15(1), 5986.
5) Xiang He, Daiqin Xiong, Lei Zhao, Jialong Fu, Lingfei Luo*. (2024). Meningeal lymphatic supporting cells govern the formation and maintenance of zebrafish mural lymphatic endothelial cells. Nature Communications 15(1), 5547.
6) Yun Yang#, Shuang Li#, Lingfei Luo*. (2024). Responses of organ precursors to correct and incorrect inductive signals. Trends in Cell Biology 34(6), 484–495.
7) Pengcheng Cai#, Rui Ni#, Mengzhu Lv#, Huijuan Liu, Jieqiong Zhao, Jianbo He,Lingfei Luo*. (2023). VEGF signaling governs the initiation of biliary-mediated liver regeneration through the PI3K-mTORC1 axis. Cell Reports42(9), 113028.
8) Xiangyong Wei#, Xinmiao Tan#, Qi Chen#, Yan Jiang, Guozhen Wu, Xue Ma, Jialong Fu, Yongyu Li, Kai Gang, Qifen Yang, Rui Ni, Jianbo He, Lingfei Luo*. (2023). Extensive jejunal injury is repaired by migration and transdifferentiation of ileal enterocytes in zebrafish.Cell Reports42(7), 112660.
9) Yun Yang#, Yuanyuan Li#, Jialong Fu#, Yanfeng Li, Shuang Li, Rui Ni, Qifen Yang, Lingfei Luo*. (2022). Intestinal precursors avoid being mis-induced to liver cells by activating Cdx-Wnt inhibition cascade. PNAS119(45), e2205110119.
10) Junren Zhang#, Yang Zhou#, Shuang Li, Dashuang Mo, Jianlong Ma, Rui Ni, Qifen Yang, Jianbo He*, Lingfei Luo*. (2022). Tel2 regulates redifferentiation of bipotential progenitor cells via Hhex during zebrafish liver regeneration. Cell Reports39(1), 110596.
11) Jingying Chen#, Xiuhua Li#, Rui Ni, Qi Chen, Qifen Yang, Jianbo He, Lingfei Luo*. (2021). Acute brain vascular regeneration occurs via lymphatic transdifferentiation. Developmental Cell56(22), 3115–3127.
12) Pengcheng Cai#, Xiaoyu Mao#, Jieqiong Zhao, Li Nie, Yan Jiang, Qifen Yang, Rui Ni, Jianbo He, Lingfei Luo*. (2021). Farnesoid X Receptor is required for the redifferentiation of bi-potential progenitor cells during biliary-mediated zebrafish liver regeneration. Hepatology74(6),3345–3361.
13) Yun Yang#, Hao Wang#, Jia He, Wenchao Shi, Zhanmei Jiang, Lina Gao, Yan Jiang, Rui Ni, Qifen Yang, Lingfei Luo*. (2021). A single-cell-resolution fate map of endoderm reveals demarcation of pancreatic progenitors by cell cycle. PNAS118(25), e2025793118.
14) Jiaobo He, Jingying Chen, Xiangyong Wei, Hui Leng, Hongliang Mu, Pengcheng Cai, Lingfei Luo*. (2019). Mammalian target of rapamycin complex 1 signaling is required for the dedifferentiation from biliary cell to bipotential progenitor cell in zebrafish liver regeneration. Hepatology70(6), 2092–2106. (封面论文)
15) Jingying Chen, Jianbo He, Rui Ni, Qifen Yang, Yaoguang Zhang, Lingfei Luo*. (2019). Cerebrovascular injuries induce lymphatic invasion into brain parenchyma to guide vascular regeneration in zebrafish. Developmental Cell49(5), 697–710. (封面论文)
16) Chi Liu, Chuan Wu, Qifen Yang, Jing Gao, Li Li, Deqin Yang*, Lingfei Luo*. (2016). Macrophages mediate the repair of brain vascular rupture through direct physical adhesion and mechanical traction. Immunity44(5), 1162–1176.