姓名🧑🏼🦳：服部素之/ Motoyuki HATTORI
职称👨🏻⚕️：研究员/Professor
职务：研究员/Professor
电子邮箱：hattorim@fudan.edu.cn
办公地点⭐️：上海市杨浦区淞沪路2005号杏鑫注册平台A201
研究方向
离子通道以及转运体的结构与功能💡，膜蛋白的表达鉴定技术研发，蛋白质从头设计。
个人简介
教育工作经历
2005年获得日本东京大学生物化学学士学位，2009年获得日本东京工业大学生命信息博士学位。2009-2012年在美国俄勒冈健康与科学大学从事博士后研究📂，2012-2015年在日本东京大学生物化学系任助理研究员及JST研究员🚴🏻♀️。
科研项目
国家自然科学基金面上项目和外青项目🧑🏻🦲、外国优秀青年项目、国际合作交流项目♛、科技部重点研发计划青年科学家专题等👩🦳。
授课情况
分子生物学课程，结构生物学课程🏋🏿♀️，现代生物化学和结构生物学训练课程
招生专业
生理和生物物理/Physiology and Biophysics
代表性论文和论著：
1. Jin F, Lin YY, Wang RC, Xie TX, Zhao Y, Shen C, Sheng D, Ichikawa M, Yu Y, Wang J*, Hattori M*. Cryo-EM structure of the zinc-activated channel (ZAC) in the Cys-loop receptor superfamily. Proc Natl Acad Sci U S A. 2024, 121(44):e2405659121.
2. Sumino A, Sumikama T, Zhao Y, Flechsig H, Umeda K, Kodera N, Konno H, Hattori M*, Shibata M*. High-Speed Atomic Force Microscopy Reveals Fluctuations and Dimer Splitting of the N-Terminal Domain of GluA2 Ionotropic Glutamate Receptor-Auxiliary Subunit Complex. ACS Nano. 2024, 18(36):25018-25035.
3. Sheng D, Yue CX, Jin F, Wang Y, Ichikawa M, Yu Y, Guo CR*, Hattori M*. Structural insights into the orthosteric inhibition of P2X receptors by non-ATP-analog antagonists. eLife. 2024, 12:RP92829.
4. Shen C, Zhang Y, Cui W, Zhao Y, Sheng D, Teng X, Shao M, Ichikawa M, Wang J*, Hattori M*. Structural insights into the allosteric inhibition of P2X4 receptors. Nat Commun. 2023, 14(1):6437.
5. Sumino A*, Zhao Y, Mukai D, Sumikama T, Puppulin L, Hattori M*, Shibata M. Antithetic effects of agonists and antagonists on the structural fluctuations of TRPV1 channel. Proc Natl Acad Sci U S A. 2023, 120(20):e2301013120.
6. Jin F, Sun M, Fujii T, Yamada Y, Wang J, Maturana AD, Wada M, Su S, Ma J, Takeda H, Kusakizako T, Tomita A, Nakada-Nakura Y, Liu K, Uemura T, Nomura Y, Nomura N, Ito K, Nureki O, Namba K, Iwata S, Yu Y, Hattori M*. The structure of MgtE in the absence of magnesium provides new insights into channel gating. PLoS Biol. 2021, 19(4):e3001231.
7. Huang Y, Jin F, Funato Y, Xu Z, Zhu W, Wang J, Sun M, Zhao Y, Yu Y, Miki H*, Hattori M*. Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter. Sci Adv. 2021, 7(7):eabe6140.
8. Jia Y, Zhao Y, Kusakizako T, Wang Y, Pan C, Zhang Y, Nureki O*, Hattori M*, Yan Z*. TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels. Neuron. 2020, 105(2):310-321.
9. Li M, Wang Y, Banerjee R, Marinelli F, Silberberg S, Faraldo-Gomez J*, Hattori M*, Swartz K*. Molecular mechanisms of human P2X3 receptor channel activation and modulation by divalent cation bound ATP. eLife. 2019, 8:e47060.
10. Wang J, Wang Y, Cui WW, Huang Y, Yang Y, Liu Y, Zhao WS, Cheng XY, Sun WS, Cao P, Zhu MX, Wang R*, Hattori M*, Yu Y*. Druggable negative allosteric site of P2X3 receptors. Proc Natl Acad Sci U S A. 2018, 115(19):4939-4944.