王永明👩🦲，博士生导师🗃。2010年获得柏林自由大学博士学位；2010-2013年在斯坦福大学医杏鑫从事博士后研究🔑🤹🏼♀️；2013年至今在杏鑫工作🧜🏻♂️🪤。王永明课题组隶属杏鑫平台遗传工程国家重点实验室，主要开发新型CRISPR工具🌌，并进行心肌病基因治疗研究。先后两次获得国家级人才计划支持。
应聘条件：
1.有小鼠操作经验、基因编辑🧿、多能干细胞培养或者心肌病研究背景的优先👷♀️🙂↔️。
2.发表过二区以上论文一篇。
工资待遇：
>40万/年
应聘方式：
请将以下应聘材料通过电子邮件发至yonmiwang@gmail.com邮箱🌷，邮件标题请注明“应聘王永明研究组博士后岗位”。初审合格后，将统一通知面试，择优录用👅。
实验室链接：
/e7/3d/c28175a386877/page.htm
主要研究方向：
1.开发新型CRISPR基因编辑工具。
2.运用CRISPR技术进行基因治疗研究。
代表性成果🪚：
1. Tao Qi, Yao Wang, Yuan Yang, Siqi Gao, Jingtong Liu, Qiang Huang, Yuwen Tian, Junnan Tang*, Wei Zheng*, Yongming Wang*. Phage-assisted evolution of compact Cas9 variants targeting a simple NNG PAM. Nature Chemical Biology. 2023 Dec 6.
2. Man Qi#, Shuhong Ma#, Jingtong Liu#, Xujie Liu, Jingjing Wei, Wen-Jing Lu, Siyao Zhang, Yun Chang, Yongshuai Zhang, Kejia Zhong, Yuting Yan, Min Zhu, Yabing Song, Yundai Chen, Guoliang Hao, Jianbing Wang, Li Wang, Andrew S Lee, Xiangbo Chen*, Yongming Wang*, Feng Lan*. In vivo base editing of Scn5a rescues type 3 long QT syndrome in mice. Circulation. 2023 Nov 15.
3. Chengdong Zhang#, Yuan Yang#, Tao Qi, Yuening Zhang, Linghui Hou, Jingjing Wei, Jingcheng Yang, Leming Shi, Sang-Ging Ong, Hongyan Wang, Hui Wang*, Bo Yu*, Yongming Wang*. Prediction of base editor off-targets by deep learning. Nature communications. 2023 Sep 2;14(1):5358.
4. Yao Wang, Tao Qi,Jingtong Liu, Yuan Yang, Ziwen Wang, Ying Wang, Tianyi Wang, Miaomiao Li,Mingqing Li, Daru Lu, Alex Chia Yu Chang, Li Yang, Song Gao, Yongming Wang*, Feng Lan*. A highly specific CRISPR-Cas12j nuclease enables allele-specific genome editing. Science Advances. 2023.
5. Gao#,Yao Wang#, Tao Qi#,Jingjing Wei, Ziying Hu, Jingtong Liu, Shuna Sun*, HuihuiLiu*, Yongming Wang*. Genomeediting with natural and engineered CjCas9 orthologs. Molecular Therapy. 2023.
6. ShuaiWang#, Chen Tao#, Huilin Mao, Linghui Hou, Yao Wang, Tao Qi, Yuan Yang, Sang-GingOng, Shijun Hu*, Renjie Chai*, YongmingWang*. Identification of SaCas9 orthologs containing a conserved serineresidue that determines simple NNGG PAM recognition. PLoS Biology. 2022.
7. Jingjing Wei, LinghuiHou, Jingtong Liu, Ziwen Wang, Siqi Gao, Tao Qi, Song Gao, Shuna Sun*, Yongming Wang*. Closely related type II-CCas9 orthologsrecognize diverse PAMs. Elife. 2022.
8. ShuaiWang, Huilin Mao, Linghui Hou, Ziying Hu, Yao Wang, Tao Qi,Chen Tao, Yuan Yang, Chengdong Zhang, Miaomiao Li, Huihui Liu, Shijun Hu,Renjie Chai*, Yongming Wang*. Compact SchCas9 Recognizes the Simple NNGR PAM. Advanced Science. 2021.
9. ShuhongMa#, Wenjian Jiang#, Xujie Liu#,Wen-Jing Lu, Tao Qi, Jingjing Wei, FujianWu, Yun Chang, Siyao Zhang, Yabing Song, Rui Bai, Jianbing Wang, Andrew S. Lee, Hongjia Zhang*, Yongming Wang*, Feng Lan*. Efficient Correction of a HypertrophicCardiomyopathy Mutation by ABEmax-NG. Circulation Research. 2021.
10. Ziying Hu #,Chengdong Zhang#, Shuai Wang, Siqi Gao, Jingjing Wei, Miaomiao Li, LinghuiHou, Huilin Mao, Yanyan Wei, Tao Qi, Hongmao Liu, Dong Liu, Feng Lan, Daru Lu, HongyanWang*, Jixi Li*, Yongming Wang*. Discoveryand engineering of small SlugCas9 with broad targeting range and highspecificity and activity. Nucleic Acids Research. 2021.